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As is shown in Figure 2, when insulin binds to IR anchored on the surface of the PDA cell, insulin activates the PI3K-AKT signal pathway to upregulate the expression of mammalian target of rapamycin (mTOR) receptor through the crosstalk with G protein-coupled receptors (GPCR) (Shen et al., 2019)

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Diabetes Metab J (2011) 35(2):14958.10.4093/dmj.2011.35.2.149 33 OhnumaKYamochiTUchiyamaMNishibashiKYoshikawaNShimizuNet alCD26 up-regulates expression of CD86 on antigen-presenting cells by means of caveolin-1